Endocrine Abstracts

Pituitary apoplexy (PA) is a rare but life-threatening medical emergency. Common predisposing factors include closed head trauma, blood pressure alterations, history of pituitary irradiation, cardiac surgery, anticoagulation, treatment with dopamine agonists, pituitary stimulation testing, and pregnancy. Hantaviruses belonging to the Bunyaviridae family are a group of rodent- or insectivore-borne single-strand ribonucleic acid (RNA) viruses. In humans, hantaviruses can cause h...

Osteopoikilosis (OPK) is a rare benign sclerotic bone dysplasia. It is inherited in an autosomal dominant pattern. There is no exact evidence of its aetiology and pathogenesis. Usually, it is an asymptomatic disease and the diagnosis is made incidentally from radiographs which show multiple, small, well-defined, variably shaped and widely distributed sclerotic areas over the skeleton. We report a family with OPK. A 22 years old woman was admitted to outpatient clinic with comp...

Introduction: A diagnosis of subacute thyroiditis (SAT) is readily suspected when patients present with a particular set of typical clinical and laboratory characteristics. We present a patient with atypical SAT who had no neck pain but presented with fever, and weight loss; had thyrotoxicosis with normal 99mTc uptake, and needed higher doses of steroids to resolve.Case report: A 57-year-old man presented with a fever (39  °C) of 2 month-durati...

Introduction: Insulinomas are rare pancreatic islet cell tumours with an incidence of four cases per million per year. About 10% of all insulinomas are malignant. We here examined an insulinoma with aggressive driving in a young male patient with severe hypoglycaemia in the emergency room.Case report: 34-year-old male patient was admitted to the emergency department with the blurring of consciousness. Blood glucose was 19 mg/dl, consciousness tends to sl...

Purpose: Paget disease is a disease of bone of unknown etiology with increased bone turnover that results in defective bone microarchitecture and bone deformity. Bisphosphonates are used in symptomatic Paget disease of bone. Clinical trials have shown that zoledronic acid was more effective than other bisphosphonates in treatment of Paget disease.Methods: In this study, we retrospectively reviewed the remission and relapse statuses of 12 patients with Pa...

Introduction: Prolactinomas are frequent in women and between 20 and 40 years but rarely seen in men especially as macroadenoma. Both in microadenomas and macroadenomes unless there is not any indication for an emergent surgery, first line treatment is always medical with dopamine agonists. In this report, we presented a patient with macroprolactinoma that disappears in a short time with dopamine agonist treatment.Case: A 20-year-old boy admitted to endo...

Introduction: Resistance to thyroid hormone (RTH) is an inherited syndrome characterized by reduced responsiveness of target tissues to thyroid hormone (TH). It is characterized by high serum concentrations of free T4 (Ft4) and usually free T3 (Ft3) accompanied by normal or slightly high serum TSH concentrations. When RTH is suspected, the diagnosis should be confirmed by direct sequencing of the TR-β gene to identify mutations....

Introduction: Warthin-like papillary thyroid carcinoma (WLPTC) is a rare variant of thyroid papillary carsinoma (TPC). We present these cases to point out this rare variant.Case reports: Case 1: A 38-year-old woman admitted to outpatient clinic with a thyroid nodule. Ultrasonography of thyroid gland revealed bilateral multinodular goiter with microcalcifications. Thyroid autoantibodies were elevated. Thyroid function tests (TFT) were normal. Fine-needle ...

Introduction: Despite having different embriogenic origins, thyroid medullary carcinoma and follicular carcinoma may be seen together as mixed medullary-follicular thyroid carcinoma. We present a rare case of mixed medullary-follicular cell carcinoma of thyroid which has a progressive and aggressive nature.Case report: A 68-year-old female patient admitted with complaint of a lump in her neck. Ultrasonography of thyroid gland revealed a 37×35 mm sol...

Objective: Gestational diabetes mellitus (GDM) is the consequence of increased insulin resistance during pregnancy in predisposed individuals who already have impaired insulin secretion due to beta-cell dysfunction as in maturity onset diabetes of young (MODY) cases. Here we aimed to document the association between MODY subtypes and GDM to understand the pathogenesis of GD.Design: Matched, case-control study.Method: Ninety-three p...